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[New human papovaviruses: JC and BK]
O Cataltepe1, D Us, S Ustaçelebi
1Hacettepe Universitesi, Tip Fakültesi Nöroşirürji Anabilim Dali.
Mikrobiyoloji Bulteni
|January 1, 1988
Summary
BK and JC viruses are common human papovaviruses. While generally asymptomatic, they can reactivate during immunosuppression and show oncogenic potential in animals, though human cancer links remain unproven.
Area of Science:
- Virology
- Oncology
- Immunology
Context:
- BK and JC viruses are ubiquitous human papovaviruses.
- Primary infections are typically asymptomatic, with reactivation occurring under immunosuppression.
- JC virus is linked to Progressive Multifocal Leukoencephalopathy (PML).
- BK virus reactivation is common post-immunosuppression.
Purpose:
- To review the characteristics and potential oncogenic properties of BK and JC viruses.
- To discuss their association with specific diseases and experimental oncogenesis.
- To evaluate the current evidence for their role in human malignancies.
Summary:
- BK and JC viruses are widespread human papovaviruses causing asymptomatic primary infections.
- Reactivation, particularly under immunosuppression, is a key clinical concern.
- Both viruses exhibit oncogenic potential in animal models.
- Currently, no direct association has been established between these viruses and human cancers.
Impact:
- Highlights the clinical significance of BK and JC virus reactivation in immunocompromised individuals.
- Underscores the need for further research into the oncogenic potential of these viruses in humans.
- Provides a concise overview for researchers and clinicians in virology and oncology.
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