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FXII promotes proteolytic processing of the LRP1 ectodomain

Lukasz Wujak1, Christina Hesse2, Katherina Sewald2

  • 1Department of Biochemistry, Universities of Giessen and Marburg Lung Center, Giessen, Germany.

Biochimica Et Biophysica Acta. General Subjects
|May 30, 2017
PubMed
Summary

Factor XII (FXII) processes the low-density lipoprotein receptor-related protein 1 (LRP1) ectodomain, impacting cell surface protein levels. This FXII-dependent LRP1 processing may drive pathological tissue remodeling.

Keywords:
Coagulation factor XIIExtracellular proteolysisLow-density lipoprotein receptor-related protein 1

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