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ASK family and cancer
Hiroki Ryuno1, Isao Naguro1, Miki Kamiyama1
1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Advances in Biological Regulation
|May 30, 2017
Summary
Apoptosis signal-regulating kinase (ASK) family members, crucial in stress response pathways, play dual roles in cancer development. Understanding their oncogenic and anti-oncogenic functions is key to cancer pathology insights.
Area of Science:
- Molecular Biology
- Oncology
- Cellular Signaling
Background:
- Cancer is a leading global health concern, with aberrant cellular signaling contributing to oncogenesis.
- Mitogen-activated protein kinase (MAPK) pathways are critical intracellular stress signaling routes implicated in cancer.
- Apoptosis signal-regulating kinase (ASK) family members (ASK1, ASK2, ASK3) are key stress-responsive molecules in MAPK cascades.
Purpose of the Study:
- To review the dual oncogenic and anti-oncogenic roles of ASK family members in cancer.
- To provide deeper insights into the involvement of ASK family members in cancer pathology.
- To explore the regulation of cellular responses like proliferation, inflammation, and apoptosis by ASK family members.
Main Methods:
- Literature review of studies on ASK family members in cancer.
- Analysis of cellular signal transduction pathways.
- Examination of stress responses and their relation to oncogenesis.
Main Results:
- ASK family members are activated by diverse stressors.
- These kinases regulate fundamental cellular processes including proliferation, inflammation, and apoptosis.
- The specific roles of ASK family members can be context-dependent, exhibiting both tumor-promoting and tumor-suppressing activities.
Conclusions:
- ASK family members are pivotal in mediating cellular responses to stress, influencing cancer development.
- Their complex roles in oncogenesis and tumor suppression warrant further investigation.
- Understanding ASK family member functions is crucial for deciphering cancer pathology and developing targeted therapies.
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