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Collaborative Research on Puerperal Infections in Bangladesh
Nobumichi Kobayashi1, Salma Ahmed1, Ayako Sumi1
1Department of Hygiene, Sapporo Medical University School of Medicine.
Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
|May 30, 2017
Summary
Puerperal infection (PI) in Bangladesh is often caused by common bacteria, with concerning rates of antibiotic resistance, particularly cephalosporin resistance in Gram-negative bacteria. This highlights the urgent need for antimicrobial resistance control in the country.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Public Health
Background:
- Bangladesh faces high risks for emerging infectious diseases due to population density, poverty, and poor sanitation.
- Focus on major diseases neglects the impact of less-understood local infections.
- Puerperal infection (PI) is a common but poorly defined complication in the perinatal period in developing countries.
Purpose of the Study:
- To investigate the incidence and bacterial causes of puerperal infections in Bangladesh.
- To determine antimicrobial drug resistance patterns and genetic traits of bacterial isolates.
- To inform future research and control strategies for infectious diseases in Bangladesh.
Main Methods:
- Prospective study over two years (2010-2012) investigating puerperal infection cases.
- Identification of aerobic bacterial species causing PIs.
- Antimicrobial susceptibility testing and investigation of genetic traits, including extended-spectrum beta-lactamase (ESBL) genes.
Main Results:
- Common bacterial isolates included Escherichia coli, Enterococcus faecalis, Staphylococcus haemolyticus, Proteus mirabilis, Staphylococcus aureus, and Klebsiella pneumoniae.
- High rates of cephalosporin resistance were observed in Gram-negative bacteria.
- Extended-spectrum beta-lactamase (ESBL) genes were prevalent, with some isolates showing carbapenem resistance.
Conclusions:
- Puerperal infection is a significant concern in Bangladesh, driven by common bacterial pathogens.
- High antimicrobial resistance rates, especially cephalosporin resistance linked to ESBLs, pose a major challenge.
- Urgent control of antimicrobial resistance and targeted research are crucial for improving maternal and child health in Bangladesh.
