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Plasma Level of Soluble ST2 in Chronically Infected HIV-1 Patients with Suppressed Viremia
Mehwish Younas1, Christina Psomas1,2, Vikram Mehraj3
1Institute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France.
Introduction:
Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease.
Observation:
Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial translocation and of T cell activation.
Results:
Here we show that it is not the case in patients with suppressed viremia. Thus, IL-33 plays its alarmin role only during the early phase of the infection.
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