Multicentric Disappearing Bone Disease treated with Arthroplasty.

Area of Science:

• Orthopedics
• Rare Diseases
• Bone Metabolism

Background:

• Gorham disease, also known as disappearing bone disease, is an extremely rare condition characterized by progressive osteolysis.
• This case highlights the challenges in diagnosing and managing multicentric Gorham disease.

Observation:

• A middle-aged woman presented with a significant bone defect in her left tibia, leading to knee joint subluxation and antalgic gait.
• She subsequently developed rapid osteolysis of her right femoral head, mimicking Gorham disease progression.
• Bone biopsy confirmed Gorham disease in both affected sites.

Findings:

• The patient underwent successful total knee replacement for her left knee, achieving pain relief.
• Following a year of radiographic monitoring to confirm cessation of osteolysis, a total right hip replacement was performed.
• Five years post-surgery, both arthroplasties remain stable, and the patient is pain-free.

Implications:

• This case demonstrates the feasibility of surgical management for Gorham disease affecting major joints.
• Successful arthroplasty in Gorham disease can lead to long-term pain relief and functional restoration.
• Early diagnosis and staged surgical intervention are crucial for optimal outcomes in multicentric Gorham disease.