Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

1.0K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.0K
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

113
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
113
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

891
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
891
Drug Distribution: Overview01:11

Drug Distribution: Overview

1.1K
Drug distribution within the body is a dynamic process involving the movement of a drug in two directions across various compartments: from the bloodstream into tissues (tissue uptake) and from tissues back into the bloodstream (tissue release or redistribution). This process is passive and primarily driven by two variables: the concentration gradient between the bloodstream and the extravascular tissues and the drug's ability to cross the cell membrane.
Initially, the free drug in the...
1.1K
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

66
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
66
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

56
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
56

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis.

Journal of the American Chemical Society·2026
Same author

Dual-Module Near-Infrared Fluorophores Discovery System via Knowledge Transfer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

White-Light-Excitable Deep-Red/NIR Organic Afterglow Nanoparticles for High-Contrast In Vivo Imaging.

Angewandte Chemie (International ed. in English)·2026
Same author

Off-On-Off Probes for Precise Theranostics.

Journal of the American Chemical Society·2026
Same author

An electron-density point-cloud framework for robust protein-ligand interaction prediction.

Nature communications·2026
Same author

An Integrated Janus Patch with Asymmetric Tissue Adhesion for Enhanced Postoperative Adhesion Prevention.

Polymer science & technology (Washington, D.C.)·2026

Related Experiment Video

Updated: Mar 1, 2026

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain
09:14

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain

Published on: May 14, 2014

12.0K

Visualization of drug delivery processes using AIEgens.

Youyong Yuan1, Bin Liu1,2

  • 1Department of Chemical and Biomolecular Engineering , National University of Singapore , 4 Engineering Drive 4 , Singapore 117585 .

Chemical Science
|May 30, 2017
PubMed
Summary

Aggregation-induced emission (AIEgens) enable advanced theranostic drug delivery systems (DDSs) for cancer therapy. These systems allow simultaneous drug delivery, bioimaging, and prediction of therapeutic responses, overcoming limitations of traditional fluorescent probes.

More Related Videos

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.6K
Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis
12:41

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Published on: December 23, 2022

5.9K

Related Experiment Videos

Last Updated: Mar 1, 2026

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain
09:14

Image-guided Convection-enhanced Delivery into Agarose Gel Models of the Brain

Published on: May 14, 2014

12.0K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.6K
Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis
12:41

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Published on: December 23, 2022

5.9K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Traditional fluorescent dye-labeled drug delivery systems (DDSs) for cancer therapy face challenges like aggregation-caused quenching (ACQ) and limited sensitivity in bioimaging.
  • Developing self-reporting DDSs that monitor drug distribution, release, and therapeutic response simultaneously is crucial for effective cancer treatment.
  • Existing fluorescent probes often require complex designs for multi-process reporting, hindering the development of advanced theranostic tools.

Purpose of the Study:

  • To review recent advancements in theranostic DDSs utilizing aggregation-induced emission characteristics (AIEgens).
  • To highlight the design principles and applications of AIEgen-based DDSs for monitoring drug delivery and therapeutic outcomes.
  • To encourage the development of sophisticated theranostic DDSs for enhanced cancer therapy and biomedical research.

Main Methods:

  • Review of literature on theranostic DDSs incorporating AIEgens.
  • Analysis of design strategies for AIEgen-based probes enabling simultaneous bioimaging and drug delivery.
  • Examination of AIEgen properties for monitoring drug distribution, activation, and predicting therapeutic responses.

Main Results:

  • AIEgens offer a solution to ACQ, enabling high signal-to-background ratio bioimaging for DDSs.
  • AIEgen-based theranostic DDSs facilitate simultaneous monitoring of drug distribution and release kinetics.
  • These novel DDSs show promise in predicting therapeutic responses, improving cancer treatment efficacy.

Conclusions:

  • AIEgens are powerful tools for developing advanced theranostic DDSs with multiple reporting capabilities.
  • AIEgen-based DDSs significantly enhance the sensitivity and functionality of cancer theranostics.
  • Further research into AIEgen-based DDSs is expected to drive innovation in personalized cancer therapy.