Glaucomatous Optic Nerve Changes and Thyroid Dysfunction in an Urban South Korean Population
Yu Sam Won1, Da Yeong Kim2, Joon Mo Kim2
1Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Journal of Ophthalmology
|May 30, 2017
Summary
This study found that while thyroid hormones like free T4 and T3 may slightly influence intraocular pressure (IOP) in healthy individuals, they are not significant risk factors for developing glaucoma. Thyroid function does not appear to independently predict glaucoma development.
Area of Science:
- Ophthalmology
- Endocrinology
- Public Health
Background:
- Intraocular pressure (IOP) is a key factor in glaucoma pathogenesis.
- Thyroid dysfunction can affect various systemic and ocular parameters.
- The relationship between thyroid function and glaucoma remains an area of investigation.
Purpose of the Study:
- To investigate the association between intraocular pressure (IOP), glaucomatous optic nerve changes, and thyroid function parameters.
- To evaluate these relationships within the Korean population.
Main Methods:
- Retrospective analysis of health screening data from Kangbuk Samsung Hospital.
- Inclusion of subjects with comprehensive systemic and ocular examinations, including fundus photography.
- Categorization of participants into glaucoma and non-glaucoma groups based on ocular findings.
- Statistical analysis of thyroid function parameters (free T4, T3, TSH) in relation to IOP and glaucoma status.
Main Results:
- Univariate analysis indicated associations between free T4, T3, and TSH with IOP in normal subjects, and T3 with IOP in thyroid disease patients.
- Multivariate analysis revealed a tendency for IOP to decrease with increasing quartiles of free T4 and T3 in normal subjects, though clinically insignificant.
- No significant correlation was found between any thyroid function tests and glaucoma development on multivariate analysis.
Conclusions:
- Thyroid function parameters (free T4, T3) show a minor, clinically insignificant tendency to decrease intraocular pressure in healthy individuals.
- Thyroid factors are not identified as independent risk factors for the development of glaucoma.
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