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Population Study Confirms Serum Proteins' Change and Reveals Diagnostic Values in Congenital Ventricular Septal

Jinghua Long1, Shun Liu1, Xiaoyun Zeng1

  • 1Department of Epidemiology School of Public Health, Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.

Pediatric Cardiology
|May 30, 2017
PubMed

Insights

Thrombospondin 1 (TSP-1), vascular endothelial-cadherin (VE-cad), and insulin-like growth factor 2 (IGF-2) show diagnostic value for ventricular septal defect (VSD). Elevated levels of these proteins in children indicate an increased risk and potential for early VSD diagnosis.

Area of Science:

  • Biomarkers
  • Cardiovascular Research
  • Pediatric Cardiology

Background:

  • Ventricular septal defect (VSD) is a common congenital heart anomaly.
  • Identifying reliable biomarkers for VSD diagnosis and risk assessment is crucial.
  • Current diagnostic methods may have limitations in early detection.

Purpose of the Study:

  • To validate thrombospondin 1 (TSP-1), vascular endothelial-cadherin (VE-cad), insulin-like growth factor 2 (IGF-2), and amyloid precursor protein (APP) as potential biomarkers for VSD.
  • To assess the diagnostic value of these proteins in a pediatric VSD cohort.
  • To explore the association between protein levels and VSD risk.

Main Methods:

  • A hospital-based case-control study involving 40 VSD children and 40 healthy controls.
  • Serum protein levels measured using enzyme-linked immunosorbent assay (ELISA).
  • Statistical analyses included logistic regression and receiver operating characteristic (ROC) curve analysis.

Main Results:

  • Serum levels of TSP-1, VE-cad, and IGF-2 were significantly elevated in VSD patients compared to controls (p < 0.05).
  • High TSP-1, VE-cad, and IGF-2 levels were strongly associated with increased VSD risk (p < 0.001 for TSP-1 and VE-cad, p = 0.015 for IGF-2).
  • ROC curve analysis indicated significant diagnostic value for TSP-1 (AUC 0.985), VE-cad (AUC 0.838), and IGF-2 (AUC 0.658).

Conclusions:

  • TSP-1, VE-cad, and IGF-2 are significantly associated with VSD risk.
  • These proteins demonstrate diagnostic potential for VSD.
  • Findings may contribute to understanding VSD etiology and improving early diagnosis and prevention strategies.

Keywords:
BiomarkersInsulin-like growth factor 2Thrombospondin 1Vascular endothelial–cadherin complexVentricular septal defect

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