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Epigenetics in Odontogenesis and its Influences.
Chuwen Li1, Yujia Cui1, Changchun Zhou1
1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University - Endodontics and Operative Dentistry, Chengdu, China.
Current Stem Cell Research & Therapy
|May 31, 2017
Summary
Epigenetic factors significantly influence tooth development (odontogenesis). Understanding these mechanisms, including DNA methylation and microRNAs, is crucial for addressing dental abnormalities and diseases.
Area of Science:
- Developmental Biology
- Epigenetics
- Dental Science
Background:
- Tooth development (odontogenesis) is primarily genome-controlled but significantly influenced by epigenetic factors.
- Environmental factors can alter DNA methylation, leading to dental variations even in identical twins.
- Epigenetic dysregulation can cause tooth malformations or agenesis.
Purpose of the Study:
- To review epigenetic mechanisms governing odontogenesis.
- To provide a foundational understanding for future research and therapies in dental diseases.
Main Methods:
- Systematic review of existing literature on epigenetics in odontogenesis.
- Categorization of epigenetic mechanisms including microRNA, DNA methylation, and histone modification.
Main Results:
- Detailed summary of reported epigenetic regulatory mechanisms in tooth development.
- Presentation of findings organized by microRNA, DNA methylation, and histone modification.
Conclusions:
- Epigenetic factors are essential regulators of cell proliferation, differentiation, and apoptosis during odontogenesis.
- These factors precisely control tooth number, size, and shape.
- Epigenetic insights are vital for understanding and treating dental developmental disorders.
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