Design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells
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Updated: Mar 1, 2026
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
Shige Wang1, Fei Hu2, Jingchao Li3
1College of Science, University of Shanghai for Science & Technology, Shanghai, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, PR China; State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, People's Republic of China.
Abstract:
The clinical translation potential of mesenchymal stem cells (MSCs) in regenerative medicine has been greatly exploited. With the merits of high surface area to volume ratio, facile control of components, well retained topography, and the capacity to mimic the native extracellular matrix (ECM), nanofibers have received a great deal of attention as bone tissue engineering scaffolds. Electrospinning has been considered as an efficient approach for scale-up fabrication of nanofibrous materials. Electrospun nanofibers are capable of stimulating cell-matrix interaction to form a cell niche, directing cellular behavior, and promoting the MSCs adhesion and proliferation. In this review, we give a comprehensive literature survey on the mechanisms of electrospun nanofibers in supporting the MSCs differentiation. Specifically, the influences of biological and physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed. Along with the significant advances in the field, current research challenges and future perspectives are also discussed.
