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Updated: Aug 8, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Viral and cellular oncogenes in papillomavirus-associated cancers
1Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.
Abstract:
Papillomaviruses are one of several factors implicated in the aetiology of squamous cell carcinomas both in man and in animals. Their potential for malignant transformation is fully expressed when co-operation takes place between viral functions, cellular functions and chemical or physical co-carcinogens. This review presents a brief description of the viral transforming genes and of the cellular genes involved in transformation, and attempts to analyse how the co-operation between the two sets of genes is achieved.
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