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Updated: Mar 1, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver
Deborah Saraggi1, Roberto Salmaso2, Elisa Valentini2
1Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy; Clinic of Plastic and Reconstructive Surgery, University of Padua, Padua, Italy.
Abstract:
A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.
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