Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

577
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
577
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

1.8K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.8K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

960
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
960
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

608
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
608
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

660
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
660
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

1.5K
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sampling strategies for selecting general population comparison cohorts.

Clinical epidemiology·2018
Same author

Erythropoiesis-stimulating agents and cardiovascular events in patients with myelodysplastic syndrome and multiple myeloma.

Clinical epidemiology·2018
Same author

Retinal vein thrombosis and risk of occult cancer: A nationwide cohort study.

Cancer medicine·2018
Same author

KRAS mutation status, comorbidity, and mortality in patients with metastatic colorectal cancer in Denmark.

Acta oncologica (Stockholm, Sweden)·2018
Same author

Risk of bleeding and arterial cardiovascular events in patients with splanchnic vein thrombosis in Denmark: a population-based cohort study.

The Lancet. Haematology·2018
Same author

Diclofenac use and cardiovascular risks: series of nationwide cohort studies.

BMJ (Clinical research ed.)·2018

Related Experiment Video

Updated: Mar 1, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

10.1K

Systemic glucocorticoid use in Denmark: a population-based prevalence study.

Kristina Laugesen1, Jens Otto Lunde Jørgensen2, Henrik Toft Sørensen1

  • 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

BMJ Open
|May 31, 2017
PubMed
Summary

Approximately 3% of Danes used systemic glucocorticoids (GCs) annually from 1999-2015. Elderly individuals had the highest GC use, up to 10%, necessitating continued awareness of their adverse effects.

Keywords:
DenmarkDrug utilisationGlucocorticoidsPrevalence

More Related Videos

A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System
13:22

A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System

Published on: September 10, 2013

12.6K
Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds
10:07

Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds

Published on: November 6, 2015

14.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

10.1K
A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System
13:22

A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System

Published on: September 10, 2013

12.6K
Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds
10:07

Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds

Published on: November 6, 2015

14.1K

Area of Science:

  • Pharmacovigilance
  • Epidemiology
  • Public Health

Background:

  • Systemic glucocorticoid (GC) use is common but linked to adverse effects.
  • Understanding GC utilization patterns is crucial for patient safety and healthcare management.

Purpose of the Study:

  • To examine the annual prevalence and amount of systemic GC use in Denmark.
  • To identify trends in GC utilization across different age groups and healthcare sectors.

Main Methods:

  • Population-wide prevalence study conducted in Denmark.
  • Data collected from primary healthcare and hospital sectors between 1999 and 2015.

Main Results:

  • Annual prevalence of systemic GC prescription users was approximately 3% of the Danish population.
  • Prevalence was highest in the elderly (up to 10%), with a slight decrease observed after age and sex adjustment.
  • Prednisolone was the most common GC, and its use increased from 1.4% to 2.1% during the study period.
  • Systemic GC amounts provided to hospitals increased, while primary care amounts remained stable.

Conclusions:

  • A significant prevalence of systemic GC use (3%) was observed, particularly in the elderly population (up to 10%).
  • Continued vigilance regarding the effects and utilization of systemic GCs is warranted.