Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.2K
Overview
85.2K
What is the Immune System?01:38

What is the Immune System?

137.8K
Overview
137.8K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

10.6K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
10.6K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.1K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.1K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.7K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Memorial: Kenneth L. Hastings, DrPH, DABT, FATS.

Journal of immunotoxicology·2026
Same author

The THP-1 cell line as a model for the assessment of monoclonal antibodies aggregates' immunological effects.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Antigen-presenting cell internalization is key for understanding and evaluating therapeutic antibodies' immunogenicity.

Frontiers in immunology·2025
Same author

Infliximab aggregates produced in severe and mild elevated temperature stress conditions induce an extended specific CD4 T-cell response.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2023
Same author

Antibodies internalization mechanisms by dendritic cells and their role in therapeutic antibody immunogenicity.

European journal of immunology·2023
Same author

Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation.

Particle and fibre toxicology·2023

Related Experiment Video

Updated: Mar 1, 2026

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry
07:31

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

Published on: March 28, 2014

18.1K

Why the Immune System Should Be Concerned by Nanomaterials?

Marc J Pallardy1, Isabelle Turbica1, Armelle Biola-Vidamment1

  • 1"Inflammation, Chimiokines and Immunopathology", INSERM UMR 996, Univ Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France.

Frontiers in Immunology
|May 31, 2017
PubMed
Summary

Nanomaterials

Area of Science:

  • Immunotoxicology
  • Nanomedicine
  • Materials Science

Background:

  • Nanomaterials possess unique properties due to their large surface area, leading to potential safety concerns.
  • Interactions with the immune system can result in immunosuppression, hypersensitivity, immunogenicity, and autoimmunity.
  • Physical and chemical characteristics of nanoparticles (NPs) influence their immunotoxicity.

Purpose of the Study:

  • To review the interactions between nanomaterials and the innate immune system.
  • To emphasize the role of antigen-presenting cells (APCs) in nanomaterial-immune interactions.
  • To explore the impact of protein aggregates in these interactions.

Main Methods:

  • Literature review focusing on nanomaterial-immune system interactions.
Keywords:
danger signalsdendritic cellsinnate immunitymacrophagesnanoparticles

More Related Videos

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

13.8K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

13.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry
07:31

Detection of Fluorescent Nanoparticle Interactions with Primary Immune Cell Subpopulations by Flow Cytometry

Published on: March 28, 2014

18.1K
Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

13.8K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

13.1K
  • Analysis of studies investigating innate immune responses to nanomaterials.
  • Emphasis on research involving dendritic cells, macrophages, and monocytes.

    • Main Results:

    • Nanomaterial properties significantly influence immune system responses.
    • Antigen-presenting cells are key players in mediating nanomaterial immunotoxicity.
    • Protein aggregation on nanomaterials can modulate immune interactions.

    Conclusions:

    • Nanomaterials present complex challenges regarding immune safety.
    • Understanding NP-APC interactions is crucial for assessing immunotoxicity risks.
    • Further research is needed to elucidate the full spectrum of nanomaterial immunomodulation.