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Quantitative HPLC determination of [99mTc]-pertechnetate in radiopharmaceuticals and biological samples--I. Technique
T Z Zhou1, W W Hirth, W R Heineman
1Department of Chemistry, University of Cincinnati, OH 45221.
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
|January 1, 1988
Abstract:
Techniques have been developed which allow HPLC (high performance liquid chromatography) to be used for the quantitative determination of [99mTc]pertechnetate in radiopharmaceuticals and biological samples. An instrumental technique accounts for 99mTc species which do not elute from the HPLC column, while a chemical technique obviates interferences caused by Sn(II). These two techniques are incorporated into an anion exchange HPLC procedure which is applied to the determination of [99mTc]pertechnetate in 99mTc-diphosphonate radiopharmaceuticals and biological samples.