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Evolving Concepts in Atopic Dermatitis
Robert Sidbury1, Kate Khorsand2
1Department of Pediatrics, Division of Dermatology, Seattle Childrens Hospital, University of Washington School of Medicine, OC 9.835, Seattle Childrens Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA. Robert.sidbury@seattlechildrens.org.
Current Allergy and Asthma Reports
|May 31, 2017
Summary
Recent advances in atopic dermatitis (AD) management are highlighted. New therapies and prevention strategies, including early emollient use, offer improved quality of life for patients with this inflammatory skin condition.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Atopic dermatitis (AD) significantly impacts patients and families medically, psychosocially, and financially.
- Epidemiologic studies reveal new associations beyond the typical atopic march.
- Understanding of atopic inflammation has advanced, identifying novel therapeutic targets.
Purpose of the Study:
- To review recent advancements in atopic dermatitis (AD) over the past five years.
- To explore developments in disease burden, comorbidities, pathogenesis, prevention, and management.
- To provide an overview of new therapeutic strategies and their clinical impact.
Main Methods:
- Literature review of recent studies on atopic dermatitis (AD).
- Analysis of epidemiological data and clinical trial outcomes.
- Synthesis of basic science research on inflammation and pathogenesis.
Main Results:
- Early emollient therapy shows significant impact on primary prevention of AD.
- New comorbidities such as ADHD and anemia are increasingly recognized in AD patients.
- Two new FDA-approved treatments, crisaborole (topical) and dupilumab (systemic), represent major therapeutic advances.
Conclusions:
- Atopic dermatitis (AD) has a profound impact on quality of life, with newly identified comorbidities.
- Advances in understanding pathogenesis have led to novel topical and systemic therapies.
- The field of AD is rapidly evolving, offering new hope for improved patient outcomes.
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