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Future clinical role for flow cytometry.

R G Ashcroft1

  • 1Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Victoria, Australia.

Cytometry. Supplement : the Journal of the Society for Analytical Cytology
|January 1, 1988
PubMed
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Flow cytometry plays an essential clinical role in oncology, offering rapid diagnosis and monitoring of cancers. High-throughput cell sorting and enumeration provide crucial early insights for improved patient outcomes.

Area of Science:

  • Clinical Oncology
  • Cell Biology
  • Diagnostic Technology

Background:

  • Flow cytometry is traditionally a supportive tool in clinical settings.
  • Its potential for essential, early diagnostic information, particularly in oncology, remains underexplored.

Purpose of the Study:

  • To highlight the essential role of flow cytometry in clinical oncology.
  • To emphasize the benefits of high flow rate cell enumeration and sorting for cancer diagnosis, monitoring, prognosis, and therapy.

Main Methods:

  • Utilizing high flow rate enumeration and sorting of rare cells combined with microscopy.
  • Implementing immediate flow cytometric measures with short measurement times.

Main Results:

  • High flow rate techniques offer immediate benefits in processing cancers, aiding in early diagnosis, monitoring, prognosis, and therapy.

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  • Shorter measurement times and on-line analysis enhance cost-effectiveness and throughput of existing facilities.

    • Conclusions:

    • Flow cytometry, especially with high flow rate sorting, is essential for early clinical oncology insights.
    • Nonsorting cytometers are inadequate for this essential clinical role; high flow rate operation should be better utilized.