A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy
Fengfeng Xue1, Ying Wen, Peng Wei
1Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, China. yitao@fudan.edu.cn.
Abstract:
We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nanoparticles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.
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