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Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media
Ana C Rodrigo1, Stephen M Bromfield, Erik Laurini
1Department of Chemistry, University of York, Heslington, York YO10 5DD, UK. david.smith@york.ac.uk.
Chemical Communications (Cambridge, England)
|May 31, 2017
Abstract:
Tuning molecular structures of self-assembling multivalent (SAMul) dendritic cationic lipopeptides controls the self-assembled morphology. In buffer, spherical micelles formed by higher generation systems bind polyanionic heparin better than worm-like micelles formed by lower generation systems. In human serum, the binding of spherical micelles to heparin is adversely affected, while worm-like micelles maintain their relative binding ability.
