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Buoyant sustained release tablets based on chitosan.

K Inouye1, Y Machida, T Sannan

  • 1Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

Drug Design and Delivery
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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Researchers developed sustained-release floating tablets using chitosan for improved drug delivery. These novel chitosan-based formulations demonstrated effective sustained drug release and absorption in beagle dogs.

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Biomaterials Science

Background:

  • Chitosan is a biocompatible polymer with potential for controlled drug release applications.
  • Intragastric floating drug delivery systems offer prolonged gastric residence time, enhancing drug absorption.
  • Developing effective sustained-release formulations remains a key challenge in oral drug delivery.

Purpose of the Study:

  • To develop and characterize sustained-release intragastric floating tablets based on chitosan.
  • To evaluate the influence of chitosan properties and formulation design on drug release and buoyancy.
  • To assess the in vivo drug absorption profile of the developed formulations.

Main Methods:

  • Two types of chitosan with varying deacetylation degrees (H and L) were utilized.

Related Experiment Videos

  • Two distinct tablet formulations (Type A and Type B) were designed and prepared.
  • Prednisolone was used as a model drug to assess sustained release characteristics in acidic media.
  • Buoyancy and drug release profiles were evaluated, followed by an in vivo absorption study in beagle dogs.

    • Main Results:

    • Both Type A and Type B formulations exhibited immediate buoyancy and sustained prednisolone release.
    • Type B formulations, featuring a foamy membrane layer, demonstrated rapid buoyancy and sustained drug release.
    • Lower drug release rates were observed with chitosan L compared to chitosan H.
    • Type B preparations resulted in sustained drug absorption in beagle dogs.

    Conclusions:

    • Chitosan-based intragastric floating tablets are effective for sustained drug release and absorption.
    • Formulation design, particularly the foamy membrane layer in Type B, significantly impacts buoyancy and release kinetics.
    • The degree of chitosan deacetylation influences drug release rate, with lower deacetylation leading to slower release.