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Published on: May 16, 2020
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Outcome predictors in dilated cardiomyopathy or myocarditis
Friedhelm Kuethe1, Marcus Franz2, Christian Jung2
1Klinik für Innere Medizin I, Ilm-Kreis-Kliniken Arnstadt, Arnstadt, Germany.
European Journal of Clinical Investigation
|May 31, 2017
Summary
Dallas-positive histopathology, ejection fraction, and beta-blocker therapy predict outcomes in chronic left ventricular dysfunction. These factors are crucial for prognosis in patients undergoing endomyocardial biopsy.
Area of Science:
- Cardiology
- Pathology
Background:
- Chronic left ventricular dysfunction affects numerous patients, necessitating prognostic markers.
- Endomyocardial biopsy is a diagnostic tool in these cases.
Purpose of the Study:
- To identify prognostic parameters in patients with chronic left ventricular dysfunction.
- To correlate endomyocardial biopsy findings with patient outcomes.
Main Methods:
- 351 patients with chronic left ventricular dysfunction underwent endomyocardial biopsy.
- Biopsies were analyzed using Dallas criteria and immunohistochemistry.
- Polymerase chain reaction detected viral genomes.
- Combined endpoint: death or heart transplantation.
Main Results:
- 19% of patients had Dallas-positive histopathology; 39% showed inflammation.
- Viral genomes were found in 58% of patients.
- Dallas-positive histopathology, ejection fraction, and beta-blocker therapy independently predicted outcomes.
Conclusions:
- Dallas-positive histopathology is a significant prognostic indicator in chronic left ventricular dysfunction.
- Beta-blocker therapy and left ventricular ejection fraction are key outcome predictors.
- These parameters are vital for managing patients with chronic left ventricular dysfunction.
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