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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis
Sanjay Campbell1, JeAnn Murray2, Rupika Delgoda3
1Department of Chemistry, University of the West Indies, Mona Campus, St. Andrew JMAAW15, Jamaica. sanjay.campbell@mymona.uwi.edu.
Abstract:
The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man's Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 1-3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (1-3) displayed moderate, concentration dependent, cytotoxicity.
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