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Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer

Theo Mantamadiotis1

  • 1Department of Pathology, School of Biomedical Sciences, University of Melbourne, Parkville 3010, VIC, Australia. theom@unimelb.edu.au.

Cancers
|May 31, 2017
PubMed

Insights

The PI3K pathway is crucial in brain cancers like gliomas. Understanding PI3K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • The phosphoinositide 3-kinase (PI3K) pathway is frequently dysregulated in human cancers, particularly gliomas.
  • Aberrant PI3K signaling, driven by mutations or altered inhibitors, promotes cancer cell survival, proliferation, migration, and differentiation.
  • The specific transcription factors regulated by PI3K in tumor cells are not fully understood.

Purpose of the Study:

  • To review the role of PI3K signaling-regulated transcription in brain cancer cells.
  • To highlight recent investigations into PI3K-mediated transcriptional regulation in gliomas.
  • To explore the therapeutic potential of targeting PI3K pathway components in brain tumors.

Main Methods:

  • Literature review of recent investigations.
  • Analysis of PI3K-responsive signaling factors and their downstream transcription factors.
  • Focus on gene expression networks regulated by PI3K in brain cancer.

Main Results:

  • PI3K signaling influences numerous transcription factors via intermediate kinases.
  • These transcription factors control gene expression networks essential for cancer cell phenotypes.
  • Recent studies provide insights into PI3K-regulated transcription in gliomas.

Conclusions:

  • Targeting PI3K signaling-regulated transcription offers a promising avenue for brain cancer therapy.
  • Developing sophisticated anti-cancer strategies may involve targeting both upstream and downstream PI3K pathway components.
  • Further understanding of PI3K-mediated transcriptional control can lead to novel therapeutic approaches.
Keywords:
CREBNFkBPI3KPTENcell signalingtranscription factors

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