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Updated: Mar 1, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Sickle cell gene in Central India: Kinship and geography
1Anthropometry and Human Genetics Unit, Indian Statistical Institute, Calcutta 700 035, India.
Abstract:
A wide range of variation (0.00-0.14) in the frequencies of the HbS allele has been observed among 16 tribes of Orissa, Madhya Pradesh, and Maharashtra. A significant excess of SS individuals over that expected under Hardy-Weinberg equilibrium was observed among 6 of 16 populations. These populations belong to three linguistic groups and have history of heterogeneous origins. A geographical cline of increase in HbS allele frequency from east to west is apparent. This pattern can largely be explained by differential migration. The kinship coefficient (rij ) and paired FST do not show any significant correleation up to 250 km of geographical distance but beyond this distance they show an inverse releationship with increasing geographic distance. Hemoglobin levels between individuals with βS allele and with normal HbA individuals do not differ in these. © 1995 Wiley-Liss, Inc.
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