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Updated: Mar 1, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Carotid artery stenting in clinical practice depending on patient age
Jakob Ledwoch1, Stephan Staubach1, Manuela Segerer1
1Klinikum Neuperlach, Klinik für Kardiologie, Pneumologie und Internistische Intensivmedizin, Städtisches Klinikum München GmbH, Oskar-Maria-Graf-Ring 51, Munich, 81737, Germany.
Insights
Older patients (≥75 years) undergoing carotid artery stenting (CAS) face higher risks of adverse events. However, age did not impact outcomes for asymptomatic patients or stroke risk post-procedure.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Geriatric Medicine
Background:
- The real-world, age-dependent outcomes of carotid artery stenting (CAS) are not well-established.
- This study evaluates acute and long-term results of CAS across different age groups in a single-center registry.
Purpose of the Study:
- To assess the impact of age on the outcomes of carotid artery stenting (CAS).
- To compare acute and long-term results of CAS in patients stratified by age (<65, 65-74, and ≥75 years).
Main Methods:
- A consecutive series of 878 patients undergoing CAS between 1999 and 2015 were analyzed.
- Patients were categorized into three age groups: <65, 65-74, and ≥75 years.
- Outcomes included a composite of 30-day death, stroke, myocardial infarction (MACCE), and long-term ipsilateral stroke.
Main Results:
- Patients aged ≥75 years had a significantly higher rate of the primary endpoint (MACCE plus long-term ipsilateral stroke) compared to the 65-74 age group (HR 2.30, P=0.001).
- The stroke endpoint was also higher in the ≥75 group versus the 65-74 group (HR 2.03, P=0.04).
- No significant age-dependent differences were observed in asymptomatic patients or for stroke risk beyond the periprocedural period.
Conclusions:
- Older patients (≥75 years) experience poorer outcomes following CAS.
- Age is not a significant factor in outcomes for asymptomatic patients undergoing CAS.
- The risk of stroke beyond the periprocedural period is not influenced by patient age.
Background:
The age-dependent outcome of carotid artery stenting (CAS) outside of randomized controlled trials is largely unknown. Therefore, we assessed acute and long-term results of CAS in a single-center real-world registry.
Methods:
All symptomatic and asymptomatic patients who consecutively underwent CAS were enrolled into the present analysis. The population was divided into three groups dependent on patients' age (<65, 65-74, and ≥75 years).
Results:
Between 1999 and 2015, a total of 878 patients (24%, <65 years; 40%, 65-74 years; and 36%, ≥75 years) underwent CAS. The rate of the primary endpoint (30-day composite of death, stroke, and myocardial infarction [MACCE] plus long-term ipsilateral stroke) was higher in patients aged ≥75 years compared to the middle-age group (hazard ratio [HR] 2.30, confidence interval [CI] 1.22-4.36; P = 0.001). Similarly, the rate of the stroke endpoint (30-day any stroke plus long-term ipsilateral stroke) was higher in patients aged ≥75 years compared to patients aged 65-74 years (HR 2.03, CI 1.01-4.10; P = 0.04). There was no significant age-dependent difference of the primary endpoint and stroke endpoint in the subset of asymptomatic patients. Furthermore, age had no influence on the risk of stroke beyond the periprocedural period.
Conclusions:
Patients aged ≥75 years had poorer outcomes after CAS compared to younger patients. Importantly, age did not influence the outcome in asymptomatic patients and the risk for stroke beyond the periprocedural period.
