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[Transcription factor p53 and skin aging].

D A Gritsenko1, O A Orlova2, N S Linkova2,3

  • 1Institute of Plant Biology and Biotechnology, Almaty, 050040, Republic of Kazakhstan.

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|May 31, 2017
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Summary

Skin aging involves slower cell renewal and increased cell death, with the p53 protein playing a key role. Balancing p53 expression is crucial for cosmetic gerontology and skin health.

Keywords:
agingskinр53 protein

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Area of Science:

  • Gerontology
  • Molecular Biology
  • Dermatology

Background:

  • Skin aging is characterized by reduced cellular renewal and a shift towards apoptosis (programmed cell death).
  • The transcription factor p53 is a critical regulator of apoptosis and its expression is notably affected by ultraviolet radiation in skin keratinocytes.
  • Mutant forms of p53 are found in a significant percentage of keratinocytes after UV exposure, impacting cellular function.

Purpose of the Study:

  • To review the molecular aspects of skin aging in the context of cosmetic gerontology.
  • To explore the role of the p53 protein in skin aging and its implications for cosmetic applications.
  • To discuss the potential of p53 as a biomarker for skin cell functionality in geroprotective treatments.

Main Methods:

  • Literature review focusing on molecular mechanisms of skin aging.
  • Analysis of the role of p53 in keratinocyte apoptosis and response to UV radiation.
  • Discussion of the balance between anti-aging effects and tumor promotion related to p53 modulation.

Main Results:

  • Aging slows cell renewal, increasing apoptosis, with p53 as a key marker.
  • UV radiation elevates p53 expression in keratinocytes, often leading to mutant forms.
  • Suppression of p53 can reduce apoptosis and slow aging but increases skin tumor risk.

Conclusions:

  • Maintaining physiological p53 balance is vital for cosmetic gerontology and skin health.
  • p53 protein serves as a potential functional marker for skin cells in geroprotective cosmetic interventions.
  • Understanding p53's role is crucial for developing effective anti-aging cosmetic strategies.