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Updated: Mar 1, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

The next chapter for group B meningococcal vaccines.

N Y Wang^1,2, A J Pollard^2,3

¹a School of Medicine , Monash University , Melbourne , Australia.

Critical Reviews in Microbiology

|May 31, 2017

Summary

New group B meningococcal vaccines show promise for controlling endemic disease in infants. Evidence of reduced carriage acquisition is crucial for herd immunity, despite challenges with dosing and reactogenicity.

Keywords:

Neisseria meningitidis factor H binding protein meningococcal disease outer membrane vesicle recombinant protein

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Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

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Last Updated: Mar 1, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

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Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

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Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

Area of Science:

Vaccinology
Microbiology
Epidemiology

Background:

Group B Neisseria meningitidis is the primary cause of invasive meningococcal disease (IMD) in developed nations.
Past vaccine successes against this pathogen were limited to specific clonal outbreaks.
The UK's routine infant immunization program marks a new era in controlling endemic group B IMD.

Purpose of the Study:

To review key developments in group B meningococcal vaccine research.
To discuss factors influencing the control of endemic group B IMD.
To assess the potential impact of new vaccines on disease control and future strategies.

Main Methods:

Review of historical and current group B meningococcal vaccine development.
Analysis of early data from the UK's routine infant immunization program.
Discussion of immunological and epidemiological evidence related to vaccine efficacy and herd immunity.

Main Results:

New group B meningococcal vaccines are being implemented for routine infant immunization in the UK.
Evidence of reduced carriage acquisition in adolescents post-vaccination is essential for herd immunity.
Challenges include the need for multiple doses and vaccine reactogenicity.

Conclusions:

Early UK data suggest new group B meningococcal vaccines can significantly impact disease rates.
Achieving population control requires demonstrating reduced carriage acquisition to enable herd immunity.
Further insights into vaccine effectiveness and future improvements are anticipated.