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Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Related Experiment Video

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Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
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Gastric Angiolipoma: A Rare Entity.

Yong-Jun Liu, Dipti M Karamchandani1

  • 1From the Department of Pathology, Penn State Milton S. Hershey Medical Center & Penn State College of Medicine, Hershey, Pennsylvania.

Archives of Pathology & Laboratory Medicine
|May 31, 2017
PubMed
Summary

Gastric angiolipomas are rare benign tumors. Accurate diagnosis is challenging, often requiring histopathology to differentiate from other gastric neoplasms.

Area of Science:

  • Gastroenterology
  • Pathology
  • Oncology

Background:

  • Angiolipomas are benign tumors of adipose and vascular tissue, typically found in subcutaneous areas.
  • Gastric angiolipomas are exceptionally rare, with limited cases reported in medical literature.
  • These tumors can manifest as gastrointestinal bleeding, anemia, or obstructive symptoms.

Purpose of the Study:

  • To review the clinical presentation, diagnostic challenges, and histopathologic features of gastric angiolipomas.
  • To highlight the importance of recognizing this rare entity in the differential diagnosis of gastric neoplasms.
  • To discuss current understanding of treatment and prognosis for gastric angiolipomas.

Main Methods:

  • Review of existing English-language literature on gastric angiolipomas.

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  • Analysis of clinical, radiologic, and histopathologic data from reported cases.
  • Comparison with differential diagnoses of benign and malignant gastric tumors.

    • Main Results:

    • Accurate preoperative diagnosis of gastric angiolipoma is difficult due to nonspecific symptoms and imaging findings.
    • Histopathologic examination remains the gold standard for definitive diagnosis.
    • Awareness of this rare entity is crucial for appropriate clinical management.

    Conclusions:

    • Gastric angiolipomas represent a rare but significant differential diagnosis for gastric lesions.
    • Multidisciplinary awareness and accurate histopathological assessment are key to diagnosis and management.
    • Further case reports may elucidate more on the clinical behavior and optimal treatment strategies.