Related Experiment Video
Updated: Mar 1, 2026
10:21
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
Published on: September 12, 2019
7.8K
Microcystic Lymphatic Malformation Successfully Treated With Topical Rapamycin
Pablo García-Montero1, Javier Del Boz2, Miguel Sanchez-Martínez3
1Departments of Dermatology and.
Pediatrics
|May 31, 2017
Summary
Topical rapamycin ointment shows promise for treating microcystic lymphatic malformations (MLM). This treatment led to significant symptom reduction and improvement in two pediatric cases with extensive MLM.
Area of Science:
- Dermatology
- Vascular Surgery
- Pediatric Medicine
Background:
- Microcystic lymphatic malformations (MLM) are challenging low-flow vascular malformations often affecting deep tissues.
- Conventional treatments for MLM have limitations, necessitating exploration of novel therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy and safety of topical rapamycin ointment in pediatric patients with microcystic lymphatic malformations.
- To present two case studies of MLM treatment using 1% rapamycin ointment.
Main Methods:
- Two pediatric patients with extensive MLM received 1% rapamycin ointment treatment.
- Treatment outcomes were assessed based on symptom reduction, complication management, and side effects.
Main Results:
- Both patients demonstrated significant clinical improvement after 4 months of topical rapamycin treatment.
- Marked reduction in discomfort, swelling, exudate, and superinfection was observed with no major side effects.
Conclusions:
- Topical rapamycin ointment is a potentially effective and safe treatment option for microcystic lymphatic malformations in pediatric patients.
- This approach offers a viable alternative before considering more aggressive systemic or intralesional therapies for MLM.
