Giant Ocular Surface Squamous Neoplasia Wrapping Whole Cornea

We present a giant ocular surface squamous neoplasia (OSSN) measuring approximately 20×18 mm arising from the fornix and wrapping the entire 12 clock hours of the cornea. The surgical excision was performed with preservation of the corneal surface. A 3-mm clear margin was obtained all around the mass. The histopathology confirmed as moderately differentiated squamous cell carcinoma with clear margins. The postoperative period was uneventful, and a clear cornea without a residual scar with best corrected visual acuity of 20/20 was attained. A giant OSSN can demonstrate corneal invasion, making surgical excision both challenging and associated with complications such as subsequent scarring. Extended surgical intervention, chemotherapy, chemoreduction, and immunotherapy have been reported in giant OSSNs. However, we report a giant OSSN wrapping the entire 12 clock hours of the cornea that was managed with single surgery with complete corneal restoration.