Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stability of structures01:14

Stability of structures

548
In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
548
Introduction to Structures01:30

Introduction to Structures

1.8K
A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
1.8K
Indeterminate Structure01:18

Indeterminate Structure

1.5K
Indeterminate structures refer to structures where internal forces and reactions cannot be determined using only the equations of static equilibrium.  Indeterminate structures have more unknown forces and reaction forces than equations of static equilibrium that can be used to determine them. Indeterminate structures are often used in engineering to create complex, efficient, and aesthetically pleasing structures. There are various types of indeterminate structures used in engineering and...
1.5K
Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

1.0K
In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
1.0K
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

4.1K
Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
4.1K
Structures of Solids02:22

Structures of Solids

19.8K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
19.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxicological impacts of environmentally equivalent microplastics and cadmium co-exposure in tropical freshwater crab <i>Sartoriana spinigera</i>.

Frontiers in toxicology·2026
Same author

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization.

Nature communications·2025
Same author

Dynamic scaling approach for a continuous horizontal blender using a small-scale image of an industrial-scale blender.

International journal of pharmaceutics·2025
Same author

Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug-treated hosts.

Parasites & vectors·2025
Same author

Comparative analysis of asphalt and geomembrane sealing systems for sustainable uranium pile remediation: Insights from hydrological modeling under climate change.

Journal of hazardous materials·2025
Same author

Selective inhibition of Mycobacterium tuberculosis GpsI unveils a novel strategy to target the RNA metabolism.

Nucleic acids research·2025
Same journal

The Role of Zn-Hf Site Proximity and Oxygen Vacancies for Methanol Formation Over ZnHfO<sub>x</sub> Catalysts Under CO<sub>2</sub> Hydrogenation Conditions.

Angewandte Chemie (International ed. in English)·2026
Same journal

Breaking the Linear Scaling Relationship: Bioinspired Electronic Coupling in S-Bridged Fe-Fe Dual Sites for Efficient Oxygen Reduction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Programming Bio-Bio Electronic Interfaces for Light-Driven Interspecies Electron Transfer.

Angewandte Chemie (International ed. in English)·2026
Same journal

Self-Cleaning Solar Evaporation Facilitating Water Electrolysis for Hydrogen Generation From Seawater.

Angewandte Chemie (International ed. in English)·2026
Same journal

Sulfur Vacancy-Enriched Cu<sub>4</sub>SnS<sub>4-x</sub> Nanosheets Enable Synergistic Cuproptosis, Photothermoelectric Catalytic and Immunotherapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Mechanically Interlocked Indigo Photoswitches.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.1K

Privileged Structures Revisited.

Petra Schneider1,2, Gisbert Schneider1

  • 1Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

Angewandte Chemie (International Ed. in English)
|May 31, 2017
PubMed
Summary
This summary is machine-generated.

Medicinal chemistry research reveals that scaffolds with fewer hydrogen-bond acceptors are less promiscuous. Easily accessible, heterocyclic, sp3-rich frameworks are ideal for designing targeted compound libraries.

Keywords:
Shannon entropycheminformaticscombinatorial chemistrymedicinal chemistrypolypharmacology

More Related Videos

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

4.5K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

9.2K

Related Experiment Videos

Last Updated: Mar 1, 2026

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.1K
Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
07:20

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

4.5K
A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

9.2K

Area of Science:

  • Medicinal Chemistry
  • Computational Chemistry
  • Drug Discovery

Background:

  • Privileged structures are key in medicinal chemistry for designing compound libraries.
  • Understanding molecular frameworks' prevalence is crucial for drug discovery.
  • Previous studies have explored privileged structures but lacked comprehensive quantitative analysis.

Purpose of the Study:

  • To analyze 1.4 million bioactive compounds for molecular framework prevalence.
  • To quantify scaffold promiscuity using Shannon entropy across target families.
  • To critically evaluate the concept of privileged structures in medicinal chemistry.

Main Methods:

  • Comprehensive analysis of 1.4 million bioactive compounds.
  • Application of Shannon entropy formalism to quantify scaffold promiscuity.
  • Assessment of atom scaffolds across annotated target families.

Main Results:

  • An inverse relationship was observed between a scaffold's hydrogen-bond-acceptor count and its promiscuity.
  • Chemically accessible scaffolds can be templates for libraries with varied target engagement.
  • Heterocyclic, sp3-rich frameworks are well-suited for target-focused library design.

Conclusions:

  • The study provides a quantitative context for narratives surrounding privileged structures.
  • Findings guide the design of compound libraries with specific target engagement profiles.
  • Scaffold accessibility and chemical properties influence library design strategies.