Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pore Transport and Ion-Pair Transport

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...

Facilitated Diffusion

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...

Transcellular Transport of Solutes

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...

Two Components: Liquid–Liquid Systems

Two Components: Liquid–Liquid Systems

A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Engineering the Self-Assembly of Bacterial Microcompartment Shell Proteins via Charged Mutations.

ACS nano·2026

Same author

Solvent-Dependent Mechanical Response of De Novo Helix Repeat Proteins.

The journal of physical chemistry. B·2026

Same author

Mechanophore cross-linking enhances ballistic energy dissipation of polymers.

Nature·2026

Same author

How Phosphorylation of How Phosphorylation of alpha/beta-Tubulin Perturbs Microtubule Structure: A Computational Study.

bioRxiv : the preprint server for biology·2026

Same author

Role of Polymer-Protein Interactions in the Dynamics of Polymer-Integrated Protein Crystals.

Journal of the American Chemical Society·2026

Same author

Nanoplastics penetration across the blood-brain barrier.

Physical chemistry chemical physics : PCCP·2026

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer

Published on: April 19, 2021

Ion Transport Mechanisms in Liquid-Liquid Interface.

Baofu Qiao¹, John V Muntean², Monica Olvera de la Cruz¹

¹Department of Materials Science and Engineering, Northwestern University , Evanston, Illinois 60208, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|May 31, 2017

Summary

This summary is machine-generated.

This study reveals that ions are transported across liquid interfaces via water channels, not extractant monolayers. This finding advances understanding of interfacial ion transport in separation processes.

More Related Videos

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

Related Experiment Videos

Last Updated: Mar 1, 2026

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer

Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer

Published on: April 19, 2021

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

Published on: September 9, 2022

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

Area of Science:

Physical Chemistry
Materials Science
Chemical Engineering

Background:

Interfacial liquid-liquid ion transport is vital for biotechnology and industrial separations.
Understanding ion transport mechanisms at interfaces is key to optimizing these processes.

Purpose of the Study:

To elucidate the mechanisms of interfacial ion transport using a model water-in-oil microemulsion system.
To investigate the role of extractants and interfacial structures in ion transfer.

Main Methods:

Atomistic molecular dynamics simulations.
Synchrotron X-ray scattering and spectroscopy.
Formulation of a water-in-oil microemulsion for simulation.

Main Results:

Lutetium(III) cations were transported from water pools to oil using a lipophilic ligand.
No evidence of interfacial extractant monolayers was observed.
Ion exchange occurred through water channels penetrating the surfactant monolayer.

Conclusions:

The oil-water interface is dynamic, facilitating ion transport.
Lipophilic ion shuttles do not require flat monolayer structures for efficient transport.
Ion transport mechanisms differ from previously hypothesized models.