Related Experiment Video
Updated: Mar 1, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Quinoline, Coumarin and Other Heterocyclic Analogs Based HIV-1 Integrase Inhibitors
Pankaj Wadhwa1, Priti Jain1, Santosh Rudrawar2,3
1Department of Pharmacy, Birla institute of Technology and Science Pilani, Pilani Campus, Pilani- 333031, Rajasthan, India.
Abstract:
Human Immunodeficiency Virus Type 1 Integrase or HIV-1 integrase (IN) is a 288 amino acid protein that incorporates the retrotranscribed viral DNA into the host chromosomal DNA. Over the past 30 years, large number of derivatives have been evaluated for their inhibitory potential against IN. There is vast literature available which need to be collated to help scientists plan the future drug design. This review discusses the reports of past 25 years on analogs of quinoline, coumarin and other related heterocycles, which exhibit low micromolar inhibitory potency against IN.
More Related Videos
Related Concept Videos
Retrovirus Life Cycles
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Subviral Agents
Retroviruses

