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Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients

Alex G Quinn1, Rachel Schwemberger1, Eveline Oestreicher Stock2

  • 1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.

Journal of Clinical Lipidology
|June 1, 2017
PubMed

Insights

Statin therapy significantly reduces prebeta-1 high-density lipoprotein (HDL), a marker linked to coronary heart disease risk. This reduction is associated with decreased triglycerides, suggesting a beneficial impact on cholesterol efflux.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Pharmacology

Background:

  • Elevated prebeta-1 high-density lipoprotein (HDL) is linked to increased atherosclerotic coronary heart disease risk.
  • Prebeta-1 HDL is the primary acceptor of cholesterol effluxed from macrophages.

Purpose of the Study:

  • To evaluate the impact of a 6-week moderate-dose statin treatment on prebeta-1 HDL levels.
  • To understand the relationship between statin therapy, lipid profiles, and prebeta-1 HDL.

Main Methods:

  • 101 patients with hypercholesterolemia or combined hyperlipidemia were treated with statins (mean atorvastatin potency equivalence 23.6 mg/d) for 6 weeks.
  • Prebeta-1 HDL levels were measured using immunofixation of agarose gels with anti-apolipoprotein A-1 antibody before and after treatment.
  • Lipid profiles, including LDL cholesterol and triglycerides, were assessed.

Main Results:

  • Statin treatment resulted in a 42.0% reduction in LDL cholesterol and a 22.3% decrease in triglycerides.
  • Prebeta-1 HDL levels significantly decreased by 17.9% post-treatment (P < .001).
  • The reduction in prebeta-1 HDL was strongly correlated with triglyceride reduction, not LDL cholesterol reduction.

Conclusions:

  • Statin therapy effectively reduces prebeta-1 HDL levels, a marker associated with coronary heart disease.
  • The observed reduction in prebeta-1 HDL may be partly due to decreased triglycerides and potentially a direct beneficial effect on cholesterol efflux.
  • These findings highlight a potential mechanism for statins' cardioprotective effects beyond LDL reduction.
Abstract

Keywords:
DyslipidemiaHDLLDLLipoproteinsPrebeta-1 HDLReverse cholesterol transportStatin treatmentTriglycerides

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