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Complement in renal transplantation: The road to translation

Neeltina M Jager1, Felix Poppelaars2, Mohamed R Daha3

  • 1Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Molecular Immunology
|June 1, 2017
PubMed

Insights

The complement system plays a critical role in kidney transplantation, contributing to injury and rejection. Complement inhibition therapies show promise for improving graft function and survival.

Area of Science:

  • Immunology
  • Nephrology
  • Transplantation Medicine

Background:

  • Renal transplantation is the primary treatment for end-stage renal disease.
  • The complement system is integral to the success and complications of kidney transplants.
  • Understanding complement's role is crucial for improving patient outcomes.

Purpose of the Study:

  • To review the multifaceted role of the complement system throughout renal transplantation phases.
  • To analyze complement's contribution to transplant injury and rejection pathogenesis.
  • To evaluate current and emerging complement-targeted therapeutic strategies.

Main Methods:

  • Comprehensive literature review of complement's involvement in renal transplantation.
  • Examination of local and systemic complement production and activation pathways.
  • Analysis of clinical trials investigating complement inhibition therapies.

Main Results:

  • Complement activation contributes significantly to renal transplant injury and rejection.
  • Specific complement pathways are implicated in donor, preservation, reperfusion, and rejection phases.
  • Therapeutic strategies targeting complement are under active clinical investigation.

Conclusions:

  • Complement inhibition is a promising therapeutic avenue for renal transplantation.
  • Targeted complement therapeutics are expected to be clinically implemented soon.
  • These therapies aim to enhance renal graft function and long-term survival.

Keywords:
ComplementKidneyTransplantation

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