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In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei
Kate E Mounsey1, Shelley F Walton2, Ashlee Innes2
1Inflammation and Healing Cluster, School of Health & Sport Sciences, Faculty of Science, Health, Education, and Engineering, University of the Sunshine Coast, Sippy Downs, Australia kmounsey@usc.edu.au.
Abstract:
Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for Sarcoptes scabieiIn vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower than that of ivermectin (0.5 μM versus 1.8 μM at 24 h; P < 0.0001). This finding provides further support for moxidectin as a candidate for the treatment of human scabies.

