[A method of protection on out-flow of hydroxyapatite]

Attelocollagen obtained by pepsin treatment from calf skin is very poor antigen. Attelocollagen is the most promising implantable biomaterial because of its lower antigenic property and excellent tissue compatibility. The purpose of this study is to examine that attelocollagen suppress an out-flow of hydroxyapatite. The subject were 16 patients with moderate to advanced periodontal disease who visited Meika university hospital. The clinical examination were performed immediately after the surgery, 1, 2, and 4 weeks after postsurgery. The remains of hydroxyapatite were measured by the roentgenograph and an image analyzer system. As a result, the hydroxyapatite in attelocollagen treated group was remained much more than of control group in 4 weeks (p less than 0.01). In clinical finding, wound healing of attelocollagen treated group was accomplished in 4 weeks and it did not prevent the wound healing of periodontal tissue.