Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

701
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
701
Stress Prevention and Stress Management Techniques III01:25

Stress Prevention and Stress Management Techniques III

395
Regular exercise and meditation serve as essential tools in managing stress and promoting physical and mental well-being.
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
395
Stress01:20

Stress

8.9K
When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
8.9K
Psychological Responses to Stress01:20

Psychological Responses to Stress

788
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
788
Components of Stress01:23

Components of Stress

596
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
596
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

809
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
809

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

A molecular glue to take down mutant BRAF.

Science signaling·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

Treating depression through G proteins.

Science signaling·2026
Same author

Sense and stromal density.

Science signaling·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026
Same author

In Science Journals.

Science (New York, N.Y.)·2026

Related Experiment Video

Updated: Mar 1, 2026

Handling Techniques to Reduce Stress in Mice
09:03

Handling Techniques to Reduce Stress in Mice

Published on: September 25, 2021

43.6K

A little stress is good.

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|June 1, 2017
PubMed
Summary

Acute psychological stress activates a neural pathway to the spleen, enhancing protection against tissue damage from ischemia. This stress response is crucial for organ protection.

Area of Science:

  • Neuroscience
  • Immunology
  • Physiology

Background:

  • Ischemic tissue damage is a significant clinical problem.
  • The sympathetic nervous system plays a role in immune responses.
  • The spleen is a key organ in immune regulation and response.

Purpose of the Study:

  • To investigate the role of sympathetic nervous system signaling in response to acute psychological stress.
  • To determine the spleen's involvement in protecting against ischemic tissue damage.
  • To elucidate the mechanisms linking psychological stress, neural signaling, and organ protection.

Main Methods:

  • Utilized rodent models to induce acute psychological stress.
  • Employed neuroanatomical tracing and electrophysiology to study sympathetic neuron activity.

More Related Videos

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

4.1K
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
06:15

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

13.9K

Related Experiment Videos

Last Updated: Mar 1, 2026

Handling Techniques to Reduce Stress in Mice
09:03

Handling Techniques to Reduce Stress in Mice

Published on: September 25, 2021

43.6K
Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

4.1K
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
06:15

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

13.9K
  • Assessed spleen immune cell populations and function.
  • Induced and evaluated ischemic tissue damage in various organs.

    • Main Results:

    • Acute psychological stress significantly activated sympathetic neurons projecting to the spleen.
    • This activation led to changes in splenic immune cell distribution and function.
    • Mice exposed to stress exhibited reduced ischemic tissue damage compared to controls.
    • Pharmacological or surgical blockade of sympathetic signaling abolished the protective effects.

    Conclusions:

    • Sympathetic nervous system signaling, triggered by acute psychological stress, plays a vital protective role against ischemic tissue damage.
    • The spleen is a critical mediator in this stress-induced protective response.
    • Targeting this neuro-immune axis may offer novel therapeutic strategies for ischemic conditions.