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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Arterial stiffness: hemodialysis versus hemodiafiltration
Adrian-Bogdan Ghigolea1,2, Mirela Gherman-Caprioara3, Argentina Raluca Moldovan1,2
1Nephrology Unit, Alba County Emergency Hospital, Alba-Iulia, Romania.
Clujul Medical (1957)
|June 1, 2017
Summary
High substitution volume online hemodiafiltration improves arterial stiffness in dialysis patients compared to high-flux hemodialysis. This method may offer cardiovascular benefits, warranting further investigation in controlled trials.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biomedical Engineering
Background:
- Arterial stiffness is a cardiovascular risk factor in dialysis patients.
- The impact of different dialysis modalities on arterial stiffness is not well-established.
- High substitution volume online hemodiafiltration (HЅV-онF) shows potential cardiovascular benefits.
Purpose of the Study:
- To investigate arterial stiffness parameters in patients undergoing HSV-онF.
- To compare arterial stiffness between HSV-онF and high-flux hemodialysis (HF-HD).
Main Methods:
- A comparative study involving 23 non-diabetic patients on HSV-онF and 23 on HF-HD.
- Arterial stiffness was assessed using the oscillometric method (Arteriograph).
- Patients had a dialysis vintage of at least 6 months.
Main Results:
- HSV-онF patients exhibited a more favorable arterial stiffness profile.
- Pulse wave velocity was significantly lower in HSV-онF compared to HF-HD (9.0±1.7 m/s vs 10.39±2.29 m/s, p=0.026).
- Augmentation indexes and diastolic reflection area were significantly elevated in HF-HD patients.
Conclusions:
- HSV-онF may exert beneficial effects on arterial stiffness in dialysis patients.
- Further research in large-scale controlled trials is recommended to confirm these findings.
- This modality could be a promising option for cardiovascular risk management in hemodialysis patients.
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