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Related Experiment Videos

Calcium antagonists and hypertension.

W G Nayler1, J S Dillon, W J Sturrock

  • 1Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.

Clinical and Experimental Pharmacology & Physiology
|February 1, 1988
PubMed
Summary

Verapamil depletes cardiac noradrenaline in rats, but this effect is reversible. Both verapamil and nisoldipine effectively lower blood pressure in spontaneously hypertensive rats, suggesting their utility in hypertension management.

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Area of Science:

  • Pharmacology
  • Cardiovascular Research
  • Neurochemistry

Background:

  • Calcium antagonists, such as verapamil, are frequently prescribed for hypertension.
  • Understanding their effects on cardiac neurotransmitters and receptor regulation is crucial.

Purpose of the Study:

  • To investigate the impact of chronic verapamil and nisoldipine therapy on cardiac noradrenaline levels and beta-1 adrenoceptor density in rats.
  • To examine the influence of these calcium antagonists on blood pressure in spontaneously hypertensive rats (SHR).

Main Methods:

  • Rats received daily oral doses of verapamil or nisoldipine for six weeks.
  • Cardiac noradrenaline levels were measured.
  • Beta-1 adrenoceptor binding studies were performed using (-)[3H]-D888.

Related Experiment Videos

  • Systolic blood pressure was monitored in Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR).

    • Main Results:

    • Verapamil treatment led to a depletion of cardiac noradrenaline (NA) without altering beta-1 adrenoceptor density.
    • The reduction in cardiac NA was rapidly reversed upon cessation of verapamil.
    • Nisoldipine did not affect cardiac NA levels.
    • Both verapamil and nisoldipine prevented the rise in systolic blood pressure in SHR rats.
    • Phenylalkylamine binding site affinity was higher in SHR hearts compared to WKY and SD rats, with no change in receptor density.

    Conclusions:

    • Verapamil's depletion of cardiac noradrenaline is a transient effect, reversible upon drug withdrawal.
    • Both verapamil and nisoldipine demonstrate efficacy in managing blood pressure in hypertensive rat models.
    • The observed differences in binding affinity may indicate specific adaptations in hypertensive hearts.