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Updated: Mar 1, 2026

Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance
Published on: January 3, 2012
RNA-based regulation in type I toxin-antitoxin systems and its implication for bacterial persistence
Bork A Berghoff1, E Gerhart H Wagner2
1Institut für Mikrobiologie und Molekularbiologie, Justus-Liebig-Universität, 35392, Giessen, Germany. Bork.A.Berghoff@mikro.bio.uni-giessen.de.
Abstract:
Bacterial dormancy is a valuable survival strategy upon challenging environmental conditions. Dormant cells tolerate the consequences of high stress levels and may re-populate the environment upon return to favorable conditions. Antibiotic-tolerant bacteria-termed persisters-regularly cause relapsing infections, increase the likelihood of antibiotic resistance, and, therefore, earn increasing attention. Their generation often depends on toxins from chromosomal toxin-antitoxin systems. Here, we review recent insights concerning RNA-based control of toxin synthesis, and discuss possible implications for persister generation.
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