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Related Experiment Video

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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CD147 and glioma: a meta-analysis.

Hui Li1, Zhouhuan Xi2, Xuejiao Dai3

  • 1Reproductive Department, Xiangya Hospital, Central South University, Changsha, China. HUILI257@hotmail.com.

Journal of Neuro-Oncology
|June 1, 2017
PubMed
Summary

High CD147 expression in glioma patients is linked to poorer survival and increased recurrence risk. This biomarker correlates with aggressive tumor features, suggesting its potential in predicting patient outcomes.

Keywords:
CD147GliomaMeta-analysis

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Area of Science:

  • Neuro-oncology
  • Molecular Pathology
  • Biomarker Research

Background:

  • Gliomas are the most prevalent primary brain tumors.
  • CD147 is a transmembrane glycoprotein implicated in various cellular processes.
  • Understanding CD147's role in glioma is crucial for prognostic assessment.

Purpose of the Study:

  • To systematically evaluate the association between CD147 expression and clinicopathological features in glioma patients.
  • To determine if CD147 expression can serve as a prognostic biomarker for glioma.
  • To investigate the relationship between CD147 and matrix metalloproteinases (MMPs) in glioma.

Main Methods:

  • A meta-analysis of 19 studies involving 1806 glioma patients.
  • Literature search across multiple databases (PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wan Fang).
  • Quality assessment using the Newcastle-Ottawa Scale; statistical analysis with Revman 5.3 and Stata 14.0.

Main Results:

  • CD147 overexpression correlated with poorer overall survival (HR=2.211) and higher recurrence risk (HR=2.20).
  • Significantly higher CD147 expression was observed in glioma tissues vs. non-cancerous tissues (OR=20.42), higher-grade tumors (OR=5.88), and larger tumors (OR=1.58).
  • Strong positive correlations were found between CD147 expression and MMP2 (OR=39.11) and MMP9 (OR=13.35). No significant association with age or gender was found.

Conclusions:

  • CD147 expression is a potential prognostic biomarker for adverse outcomes in glioma patients, including reduced overall and relapse-free survival.
  • Elevated CD147 levels are associated with aggressive clinicopathological features of glioma.
  • CD147 may play a role in glioma progression, potentially through its interaction with MMPs.