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Emerging Targets of Diuretic Therapy
C-J Cheng1, A R Rodan2, C-L Huang3
1Department of Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan.
Clinical Pharmacology and Therapeutics
|June 1, 2017
Summary
New diuretic and aquaretic therapies targeting renal salt and water reabsorption are emerging. Promising agents, including WNK-SPAK inhibitors and channel antagonists, show potential for treating hypertension, edema, and heart failure.
Area of Science:
- Nephrology
- Pharmacology
- Molecular Biology
Background:
- Diuretics are essential for managing hypertension, edema, and heart failure.
- Understanding renal salt and water reabsorption mechanisms is key to developing new therapies.
- Proteins regulating these processes are novel therapeutic targets.
Purpose of the Study:
- To review emerging diuretic and aquaretic agents.
- To highlight novel therapeutic targets in renal salt and water regulation.
- To discuss the potential of new agents for preclinical testing.
Main Methods:
- Integrative high-throughput screening.
- Protein structure analysis.
- Chemical modification of identified agents.
Main Results:
- Identification of promising agents for preclinical testing.
- WNK-SPAK inhibitors, ClC-K channel antagonists, ROMK channel antagonists, pendrin, and urea transporter inhibitors are highlighted.
- Potential advantages and side effects of these agents are discussed.
Conclusions:
- Novel therapeutic strategies targeting renal transporters offer promise for diuretic and aquaretic therapy.
- Further preclinical development is warranted for identified agents.
- These advancements could lead to improved treatments for cardiovascular and renal conditions.
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