Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

824
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
824
Self-Regulation01:25

Self-Regulation

296
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
296
Stress and Mental Health01:30

Stress and Mental Health

1.0K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
1.0K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

1.0K
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.0K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

1.1K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.1K
Altered States of Awareness01:06

Altered States of Awareness

1.3K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining the link between social emotion regulation and relationship satisfaction at dyad and individual levels of analysis.

Research square·2026
Same author

Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.

Human brain mapping·2026
Same author

Neural representations of popularity and leadership status relate to conformity in daily life.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Thyroid hormones as permissive regulators of skeletal muscle protein accretion and oxidative capacity: Implications for resistance and endurance training.

Best practice & research. Clinical endocrinology & metabolism·2026
Same author

Animal models relevant to digital technology-based disorders.

Journal of behavioral addictions·2026
Same author

Latent neural architecture organising shared aesthetic evaluations of visual artworks.

Nature communications·2026

Related Experiment Video

Updated: Mar 1, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.9K

Emotion regulation deficits in regular marijuana users.

Kaeli Zimmermann1, Christina Walz2,3, Raissa T Derckx1

  • 1Department of Psychiatry and Division of Medical Psychology, University of Bonn, Bonn, 53105, Germany.

Human Brain Mapping
|June 1, 2017
PubMed
Summary

Regular marijuana users show impaired emotion regulation, with increased frontal brain activity and reduced amygdala control. This suggests disrupted brain networks may contribute to substance use.

Keywords:
amygdalamarijuana usenegative affectprefrontal cortexreappraisal

More Related Videos

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
06:09

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Published on: May 30, 2025

851
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 1, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.9K
Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
06:09

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Published on: May 30, 2025

851
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Research

Background:

  • Effective regulation of negative emotions is crucial for mental health.
  • Impaired emotion regulation is a risk factor for substance use disorders.
  • Marijuana use is associated with altered emotional processing.

Purpose of the Study:

  • To investigate behavioral and neural indicators of emotion regulation in regular marijuana users.
  • To compare emotion regulation success and brain activity between marijuana users and nonusing controls.
  • To explore the relationship between marijuana use and amygdala-prefrontal cortex connectivity during emotion regulation.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to examine brain activity during a cognitive emotion regulation (reappraisal) task.
  • Behavioral measures assessed emotion regulation success.
  • Participants included regular marijuana users (n=23) and demographically matched nonusing controls (n=20).

Main Results:

  • Marijuana users exhibited increased neural activity in bilateral frontal regions (precentral, middle cingulate, supplementary motor) during negative affect reappraisal.
  • Users showed impaired emotion regulation success on a behavioral level.
  • Impaired amygdala downregulation and decreased amygdala-dorsolateral prefrontal cortex functional connectivity were observed in marijuana users.

Conclusions:

  • Findings suggest marijuana users may attempt compensatory neural recruitment due to disrupted amygdala-prefrontal interactions during emotion regulation.
  • Impaired volitional regulation of negative affect could be a consequence of, or risk factor for, regular marijuana use.
  • These results highlight the potential neurobiological underpinnings of substance use disorders related to emotion dysregulation.