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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

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Strategies for long-term preservation of kidney graft function

Thomas Wekerle1, Dorry Segev2, Robert Lechler3

  • 1Department of Surgery, Section of Transplantation Immunology, Medical University of Vienna, Vienna, Austria.

Lancet (London, England)
|June 1, 2017
PubMed

Insights

Kidney transplantation survival rates exceed 95% at one year, but long-term graft function remains challenging. Innovations in molecular diagnostics and immunology aim to improve long-term kidney transplant outcomes.

Area of Science:

  • Nephrology and Transplant Immunology
  • Computational Biology and Precision Medicine

Background:

  • Kidney transplantation is a standard treatment for kidney failure, involving multidisciplinary teams.
  • While 1-year graft survival is high (>95%), enhancing long-term allograft function is a key challenge.
  • Donor and recipient matching, graft logistics, and long-term outcomes require continuous improvement.

Purpose of the Study:

  • To review current advancements in kidney transplantation.
  • To highlight innovations improving donor-recipient matching and long-term graft preservation.
  • To discuss future directions in transplant medicine, including tolerance induction.

Main Methods:

  • Review of current practices and emerging technologies in kidney transplantation.
  • Integration of molecular immunology and computational biology for enhanced matching.
  • Application of omics-wide diagnostics and novel therapeutic strategies.

Main Results:

  • Advanced molecular matching (HLA and non-HLA) improves donor-recipient compatibility.
  • Individualized diagnostics and therapies enable precise treatment decisions.
  • Emerging innovations are being implemented in transplant centers for better outcomes.

Conclusions:

  • Continued advancements in molecular immunology and computational biology are crucial for improving long-term kidney transplant success.
  • Personalized medicine approaches, including omics-wide diagnostics and novel therapies, offer significant potential.
  • Tolerance induction represents a future goal for minimizing immunosuppression and enhancing graft longevity.

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