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Data Commons to Support Pediatric Cancer Research.

Samuel L Volchenboum1, Suzanne M Cox1, Allison Heath1

  • 1From the University of Chicago, Chicago, IL; Children's Hospital of Philadelphia, Philadelphia, PA.

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Cancer research generates vast data, overwhelming scientists. Centralizing data and tools in data commons enhances research efficiency, power, and impact, especially in pediatric oncology.

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Area of Science:

  • Biomedical research
  • Cancer genomics
  • Data science

Background:

  • High-throughput biomedical data is rapidly increasing in volume and complexity.
  • Current research capacity is challenged by the sheer amount of cancer data.
  • Data sharing is crucial for advancing cancer surveillance and treatment.

Purpose of the Study:

  • To describe the operational models of current oncology data commons.
  • To outline practical steps and considerations for building data commons.
  • To highlight the benefits of data commons in pediatric cancer research.

Main Methods:

  • Review of existing oncology data commons.
  • Case study analysis of the International Neuroblastoma Risk Group (INRG) data commons.
  • Discussion of practical implementation strategies for data commons.

Main Results:

  • Data commons centralize data, processing power, and tools for shared resource utilization.
  • The INRG data commons serves as a model for data sharing in neuroblastoma research.
  • Building data commons requires careful planning regarding infrastructure, governance, and accessibility.

Conclusions:

  • Data commons offer a solution to manage and leverage large-scale biomedical research data.
  • Centralized resources significantly improve research efficiency, power, and impact.
  • Pediatric cancer research can particularly benefit from data commons, accelerating clinical oncology advancements.