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Fetal response to intramuscular epinephrine for anaphylaxis during maternal penicillin desensitization for secondary

Shan Shan Wu1, Tina Abraham2, Chelsea Michaud2

  • 1a Internal Medicine Residency Program , University Hospitals Regional Hospitals , Richmond Heights , OH , USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|June 1, 2017
PubMed

Penicillin desensitization is indicated in pregnant patients with severe allergies to penicillin with syphilis. The immediate effects of intramuscular epinephrine on the fetus during desensitization remain unreported. We describe a pregnant patient with secondary syphilis and penicillin allergy who developed anaphylaxis during penicillin desensitization. Anaphylaxis resolved after administration of intramuscular epinephrine. Throughout the procedure, continuous electronic fetal monitoring showed a stable fetus without a decrease in variability, tachycardia, decelerations, or signs of fetal distress. This case showed that intramuscular epinephrine is effective in treatment of anaphylaxis in a pregnant patient with little to no immediate effects on the fetus.

Keywords:
Epinephrineanaphylaxisdesensitizationfetussyphilis

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