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Updated: Mar 1, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
Use of Skin Biopsies Among Dermatologists
David A Weinstein1, Sasank Konda, Brett M Coldiron
1*Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, Florida; †TriHealth Good Samaritan Hospital, Cincinnati, Ohio; ‡University of Chicago Pritzker School of Medicine, Chicago, Illinois; §Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio; and ‖The Skin Cancer Center, Cincinnati, Ohio.
Background:
Skin biopsies are essential to establish a diagnosis in many skin diseases. Utilization has been increasing rapidly and represents a significant health care cost. There are no benchmarks or baselines to guide the practice of skin biopsies.
Objective:
To create a reference data set of biopsy behavior among dermatologists.
Methods:
Five hundred eighty-eight dermatologists belonging to the American Dermatological Association (ADA) were surveyed. Two hundred eighty-seven responded with 128 of those providing biopsy data.
Results:
The mean percentage of biopsies that were malignant was 44.5%. This varied by subspecialty with a mean of 41.7%, 57.4%, and 4.1% of biopsies performed by general dermatologists, Mohs micrographic surgeons, and pediatric dermatologists, respectively. By category or diagnosis, the biopsies were 22.7% basal cell carcinoma, 12.0% SCC, 10.2% benign neoplasms, 10.0% nevi, 8.0% actinic keratosis, 7.6% seborrheic keratosis, 7.5% inflammatory disorders, 6.1% SCC in situ, 5.3% dysplastic nevus, 5.1% benign skin, 1.5% melanoma in situ, 1.4% melanoma, 0.9% lentigines, 0.8% other malignancies, 0.6% infectious, 0.2% not otherwise specified, and 0.1% atypical lesions. There was a statistically significant difference in biopsy results between different dermatological subspecialties.
Conclusion:
These results should help elucidate dermatologic practice patterns and thus create opportunities to improve dermatologic care and reduce health care costs.
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