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New findings of oxidative stress biomarkers in nutritional research
Bastian Kochlik1, Tilman Grune, Daniela Weber
1aDepartment of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbruecke (DIfE) bNutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal cGerman Center for Diabetes Research (DZD), Munich dGerman Center for Cardiovascular Research (DZHK), Berlin, Germany *Bastian Kochlik and Daniela Weber contributed equally to the article.
Purpose Of Review:
The aim of this article is to present a brief overview of recently published articles assessing oxidative stress markers in nutritional studies.
Recent Findings:
Intervention and observational studies were carried out in both, healthy subjects and patients and describe the association of foodstuffs as well as isolated nutrients with biomarkers of oxidative stress. The results from human intervention studies on healthy participants and patients are controversial. Long-term interventions (>8 weeks) seem to be more effective than short-term or single-dose interventions. Results are difficult to compare because not only the methods used, also the assessed biomarkers and outcomes were very diverse. In addition, studies vary in the compounds and doses used, duration, participants and so on. Different biomarkers (damaged molecules together with antioxidants from different compartments) should be assessed to evaluate the true 'redox-status' of an individual and the impact of a nutritional intervention.
Summary:
Both observational and interventional studies performed in healthy participants and patients show possible beneficial effects of nutrients and foodstuffs by improving oxidative stress markers and antioxidant enzyme activities. Biomarkers should be standardized to allow better comparison of results of antioxidant intervention studies.
